A Case of Suspected Isotretinoin-Induced Malformation in a Baby of a Mother Who Became Pregnant One Month after Discontinuation of the Drug.
10.3349/ymj.2009.50.3.445
- Author:
Soon Min LEE
1
;
He Min KIM
;
Jun Seok LEE
;
Choon Sik YOON
;
Min Soo PARK
;
Kook In PARK
;
Ran NAMGUNG
;
Chul LEE
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. minspak@yuhs.ac
- Publication Type:Case Report
- Keywords:
Isotretinoin;
malformation
- MeSH:
Abnormalities, Drug-Induced/*diagnosis/*etiology/pathology;
Adult;
Female;
Humans;
Infant, Newborn;
Isotretinoin/*adverse effects;
Male;
Pregnancy;
*Prenatal Exposure Delayed Effects
- From:Yonsei Medical Journal
2009;50(3):445-447
- CountryRepublic of Korea
- Language:English
-
Abstract:
Isotretinoin is a known human teratogen that can cause multiple malformations. At present, women who conceive one cycle after discontinuing isotretinoin are told that their teratogenic risk is not higher than baseline. We present a case of both ear malformation in a newborn whose mother had taken isotretinoin for 2 years until one month prior to the time when she became pregnant. We suggest that further studies of pharmacokinetics and malformation of isotreinoin are needed.
