Clinicopathological analysis of 12 cases of children synovial sarcoma

VernacularTitle:儿童滑膜肉瘤12例临床病理学分析
Author: Yanfei LIU ^{1
,

2} ; Chao JIA ; Meng ZHANG ; Guangsheng CHEN ; Nan ZHANG ; Libing FU ; Lin WANG ; Lejian HE
Author Information

1. 首都医科大学附属北京儿童医院病理科100045
2. 西安交通大学附属西安市儿童医院病理科710043
Keywords: Sarcoma,synovial; Immunohistochemistry; Pathology,molecular
From: Chinese Journal of Pathology 2019;48(9):705-709
CountryChina
Language:Chinese
Abstract: Objective To investigate histopathological characteristics, and differential diagnoses of childhood synovial sarcoma. Methods HE staining, immunohistochemical staining and fusion gene detection by FISH were performed in 12 cases of synovial sarcoma in childhood at Beijing Children′s Hospital from 2016 to 2018. Results There were 6 cases of biphasic type,1 case of monophasic epithelial type,3 cases of monophasic spindle cell type and 2 cases of poorly differentiated synovial sarcomas. EMA, CKpan, bcl?2, CD99, TLE1 and CD34 immunostain positivities were observed in 10/12, 9/12, 12/12, 10/12, 10/12 and 0/12 cases respectively. Unique INI1 immunohistochemical staining was observed in 9/12 cases. SS18?SSX gene fusion was detected in 8 of 11 cases by FISH.Conclusions Synovial sarcoma is rare in children. Histological morphology combined with immunohistochemistry and FISH SS18?SSX fusion gene detection are important for the diagnosis and differential diagnosis of synovial sarcoma in children.