Exploration and Practice of Safe Access System Construction for Barrier Environment Facilities of Laboratory Animals: A Case Study on Xianlin Campus of Nanjing University
10.12300/j.issn.1674-5817.2024.106
- VernacularTitle:实验动物屏障环境设施安全准入体系建设的探索与实践——以南京大学仙林校区为例
- Author:
Dongxia HOU
1
;
Zuoxiu TIE
2
;
Yong LU
1
;
Panpan NAN
3
;
Jie BAO
1
Author Information
1. School of Life Sciences, Nanjing University, Nanjing 210023, China
2. College of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, China
3. Laboratory and Equipment Management Office, Nanjing University, Nanjing 210023, China
- Publication Type:Journal Article
- Keywords:
Laboratory animal;
Barrier environmental facility;
Access management;
Biosafety
- From:
Laboratory Animal and Comparative Medicine
2025;45(1):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Laboratory animals are essential in scientific research and experimental teaching in colleges and universities. Disciplines such as life sciences, medicine, pharmacy, chemistry, and biomedical engineering heavily rely on animal experiments. The standardized barrier environmental facility for laboratory animals provides a fundamental platform for stable, scientific, and reliable animal experiment results. Rigorous access management for such facilities is a vital safeguard for maintaining standardized operations of facilities, controlling the quality and stability of laboratory animals, mitigating pathogen contamination risks among animals and laboratory staff, and preventing biosecurity incidents such as zoonotic disease outbreaks. Taking the small-scale barrier facilities for laboratory rats and mice at Nanjing University's Xianlin Campus, operational since 2019, as an example, this study focuses on the safety access management system of these facilities. Based on five years of operational data and accumulated experience in studying and optimizing the access management system, this study, from the perspectives of management system development and the formulation and implementation of standard operating procedures, reviews five aspects of access management: personnel access, animals access, material access, equipment access, and air circulation control. Furthermore, these aspects are systematically analyzed and summarized to serve as a reference for the construction and management of the laboratory animal facilities in universities, while also contributing to scientific research, public health security, and the well-being of experimental personnel.
