Research Progress on Animal Models for Hernia Diseases and New Hernia Repair Materials
10.12300/j.issn.1674-5817.2024.121
- VernacularTitle:疝疾病动物模型研究及新型疝修补材料应用进展
- Author:
Bin FEI
1
;
Wenke GUO
2
;
Jianping GUO
2
Author Information
1. Fenyang College, Shanxi Medical University, Fenyang 032200, China
2. Fenyang Hospital Affiliated to Shanxi Medical University, Fenyang 032200, China
- Publication Type:Journal Article
- Keywords:
Hernia;
Animal model;
Repair material;
Research progress
- From:
Laboratory Animal and Comparative Medicine
2025;45(1):55-66
- CountryChina
- Language:Chinese
-
Abstract:
Hernia is a common and frequently occurring condition in general surgery, referring to the displacement of an organ or part of an organ from its normal anatomical position through a congenital or acquired weak point, defect, or space into another area. Its pathogenesis is complex, involving multiple factors such as abdominal wall weakness or increased intra-abdominal pressure. The clinical manifestations of hernia vary depending on its type, location, and severity. As the aging of the population continues to advance, the incidence of hernia has been increasing annually. Animal models serve as an important tool in hernia research. They enable the evaluation of the safety and efficacy of new repair materials and techniques, as well as assisting clinicians in developing new surgical methods and investigating the mechanisms and novel therapies for certain hernia diseases and their complications. Given the significant differences in the pathophysiological mechanisms of different types of hernia diseases, the methods and evaluation criteria for establishing animal models are highly diverse. Furthermore, the methods for establishing animal models are closely related to experimental objectives, and different experimental goals require different animal models. Therefore, selecting appropriate animal models based on experimental objectives is crucial for ensuring the smooth progress of research and obtaining reliable results. To this end, this review summarizes effective methods for establishing animal models for external abdominal hernias (including incisional hernia, inguinal hernia, umbilical hernia, parastomal hernia, incarcerated hernia, and pelvic floor hernia), congenital diaphragmatic hernia, hiatal hernia, and cerebral hernia. It provides a detailed analysis of the advantages, disadvantages, and evaluation criteria of these models. Additionally, this review summarizes recent preclinical applications of new hernia repair materials, aiming to provide references for animal experimental research in the field of hernia studies.
