Dynamic Monitoring and Correlation Analysis of General Body Indicators, Blood Glucose, and Blood Lipid in Obese Cynomolgus Monkeys
10.12300/j.issn.1674-5817.2024.091
- VernacularTitle:肥胖食蟹猴一般身体指标、血糖、血脂的动态监测及相关性分析
- Author:
Yanye WEI
1
;
Guo SHEN
1
;
Pengfei ZHANG
1
;
Songping SHI
1
;
Jiahao HU
1
;
Xuzhe ZHANG
1
;
Huiyuan HUA
2
;
Guanyang HUA
2
;
Hongzheng LU
2
;
Yong ZENG
1
;
Feng JI
1
;
Zhumei WEI
1
Author Information
1. Guangxi Huaren Jiying Biotechnology Co., Ltd., Nanning 530000, China
2. Laibin Xingui Biotechnology Co., Ltd., Laibin 546108, China
- Publication Type:Journal Article
- Keywords:
Obesity;
Cynomolgus monkey;
Body indicator;
Blood glucose;
Blood lipid;
Correlation analysis
- From:
Laboratory Animal and Comparative Medicine
2025;45(1):30-36
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThis study aims to investigate the dynamic changes in general body parameters, blood glucose, and blood lipid profiles in obese cynomolgus monkeys, exploring the correlations among these parameters and providing a reference for research on the obese cynomolgus monkey model. Methods30 normal male cynomolgus monkeys aged 5 - 17 years old (with body mass index < 35 kg/m² and glycated hemoglobin content < 4.50%) and 99 spontaneously obese male cynomolgus monkeys (with body mass index ≥35 kg/m² and glycated hemoglobin content < 4.50%) were selected. Over a period of three years, their abdominal circumference, skinfold thickness, body weight, body mass index, fasting blood glucose, glycated hemoglobin, and four blood lipid indicators were monitored. The correlations between each indicator were analyzed using repeated measurement ANOVA, simple linear regression, and multiple linear regression correlation analysis method. Results Compared to the control group, the obese group exhibited significantly higher levels of abdominal circumference, skinfold thickness, body weight, body mass index, and triglyceride (P＜0.05). In the control group, skinfold thickness increased annually, while other indicators remained stable. Compared with the first year, the obese group showed significantly increased abdominal circumference, skinfold thickness, body weight, body mass index, triglyceride, and fasting blood glucose in the second year(P＜0.05), with this increasing trend persisting in the third year (P＜0.05). In the control group, the obesity incidence rates in the second and third years were 16.67% and 23.33%, respectively, while the prevalence of diabetes remained at 16.67%. In the obese group, the diabetes incidence rates were 29.29% and 44.44% in years 2 and 3, respectively. Among the 11-13 year age group, the incidence rates were 36.36% and 44.68%, while for the group older than 13 years, the rates were 28.13% and 51.35%. Correlation analysis revealed significant associations (P＜0.05) between fasting blood glucose and age, abdominal circumference, skinfold thickness, body weight, and triglyceride in the diabetic monkeys. Conclusion Long-term obesity can lead to the increases in general physical indicators and fasting blood glucose levels in cynomolgus monkeys, and an increase in the incidence of diabetes. In diabetic cynomolgus monkeys caused by obesity, there is a high correlation between their fasting blood glucose and age, weight, abdominal circumference, skinfold thickness, and triglyceride levels, which is of some significance for predicting the occurrence of spontaneous diabetes.
