Retrospective study on the influence of smoking,overweight and alcoholism on femoral head necrosis after internal fixation of femoral neck fracture
10.3969/j.issn.1005-6483.2024.05.024
- VernacularTitle:吸烟、超重和酗酒共同影响股骨颈骨折内固定术后股骨头坏死的回顾性研究
- Author:
Yang GAO
1
;
Haipeng DONG
;
Feng LIU
;
Wenjuan WANG
;
Chao LIU
Author Information
1. 050000 石家庄市第三医院创伤一科
- Keywords:
femoral neck fractures;
osteonecrosis of the femoral head;
smoking;
overweight;
bibulosity;
PAI-1
- From:
Journal of Clinical Surgery
2024;32(5):525-528
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigating the relationship between smoking,overweight,and bibulosity with plasma PAI-1 and osteonecrosis of the femoral head after internal fixation by retrospective study,and providing reference for clinical treatment.Methods A total of 95 patients with femoral neck fracture treated with internal fixation from January 2021 to January 2022 were retrospectively studied.The data of smoking,overweight,alcohol abuse,preoperative and postoperative plasma PAI-1 levels were collected.The patients were divided into necrosis group and non-necrosis group according to the occurrence of femoral head necrosis at the last follow-up.Univariate analysis was performed on smoking,overweight,alcohol abuse,plasma PAI-1 level before and 2 days after operation,and the presence of smoking,overweight and bibulosity factors was analyzed.The association of smoking,overweight and bibulosity with plasma PAI-1 level was analyzed.Figure out the relationship between smoking,overweight,bibulosity and plasma PAI-1 and femoral head necrosis after internal fixation.Results Femoral head necrosis occurred in 22 of 95 patients.Age,gender,smoking,overweight and bibulosity were not independent risk factors for postoperative femoral head necrosis(P＞0.05).The plasma PAI-1 level at 2 days after operation in necrosis group was(46.95±2.35)ng/ml,which was significantly higher than that in non-necrosis group[(41.94±4.73)ng/ml,P＜0.05].The level of plasma PAI-1 at 2 days after operation was(48.29± 1.78)ng/ml in patients with smoking,overweight and alcohol abuse at the same time,which was significantly higher than that in other patients[(42.40±4.60 ng/ml,P＜0.05].In addition,when the smoking,overweight,and bibulosity were concurrent,it was a risk factor for femoral head necrosis(P＜0.05).Conclusion When the smoking,overweight,and bibulosity were concurrent,it can increases the risk of osteonecrosis of the femoral head after internal fixation,which may be related to the significant increase of plasma PAI-1 level,especially at 2 days after surgery.
