Roles of HPV detection in 28 923 patients with atypical squamous cells of undetermined significance:analysis of 104 studies from China
10.3760/cma.j.issn.0529?5807.2018.04.008
- VernacularTitle:人乳头状瘤病毒检测在28923例不能明确意义的不典型鳞状细胞患者中的应用:中国104项研究汇总分析
- Author:
Zeni WU
1
;
Zheng SU
;
Wen CHEN
;
Youlin QIAO
Author Information
1. 100021,国家癌症中心/中国医学科学院 北京协和医学院肿瘤医院流行病学研究室
- Keywords:
Cervix uteri;
Cytological techniques;
Atypical squamous cells of unknown significance
- From:
Chinese Journal of Pathology
2018;47(4):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the human papillomavirus(HPV)positive rate and its usefulness in predicting CIN2+ in women with atypical squamous cells of undetermined significance(ASC?US)cervical cytology. Methods A pooled analysis was conducted using published data of hospital classification,HPV positive rate and histopathologic diagnosis in ASC?US population during 2005 to 2017 from 104 studies which enrolled 28 923 ASC?US samples. Results The overall HPV positive rate was 52.09%(range from 12.06% to 88.68%). The HPV positive rate in 79 tertiary hospitals of 21 244 cases was 52.46%,slightly higher than the 50.87% in 22 second?class hospitals of 6 925 cases. There was no significant difference between specialized hospitals and general hospitals. In addition, the positive rate of HC2 conducted in 66 hospitals with 19 791 cases was 53.13%, which was slightly higher than 51.10% of reverse hybridization from 24 hospitals with 6 338 cases. In 73 studies of 18 163 cases with histological diagnosis, the sensitivity of HPV for detecting CIN2+ was 90.16%(95%CI:88.91% to 91.28%), specificity was 53.08%(95%CI:53.02% to 54.57%),positive predictive value was 23.24% and negative predictive value was 97.24%. Conclusion HPV detection is clinically validated for ASC?US triage, but there is a wide variation of HPV positive rate in population of cervical cytological diagnosis as ASC?US in China, suggesting different diagnostic level between regions and hospitals and further improvement is needed.
