Significance and prognostic value of integrin α5,β1 and β2 in colorectal cancer
10.3969/j.issn.1005-6483.2024.05.018
- VernacularTitle:结直肠癌中整合素α5、β1、β2表达的意义及其评估预后的价值
- Author:
Meng LI
1
;
Qianyang NI
;
Suyang YU
;
Yan ZHANG
;
Hongyan LI
Author Information
1. 050051 河北医科大学第三医院胃肠外科
- Keywords:
colorectal cancer;
integrin α5;
integrin β1;
integrin β2;
prognosis
- From:
Journal of Clinical Surgery
2024;32(5):502-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance and prognostic value of integrin α5,β1 andβ2 in colorectal cancer(CRC).Methods The clinical data of 187 patients with CRC who were diagnosed in the hospital from January 2017 to January 2018 were analyzed retrospectively.The expression of integrin α5,β1and β2 in cancer tissues and adjacent tissues,and its relationship with pathological characteristics of CRC were analyzed.All patients were followed up for 5 years after operation.Postoperative recurrence and survival time were recorded.Results The positive expression rates of integrin α5,β1 and β2 in cancer tissues were higher than adjacent tissues(P＜0.05).There was no statistically significant difference in the expression levels of integrin α5,β1 and β2 in patients of different gender,patients of different age and patients with different tumor diameters(P＞0.05).The expression levels of integrin α5,β1 and β2 in patients with different differentiation degrees,patients in different TNM stages,and patients with and without lymph node metastasis were significantly different(P＜0.05).All of the 187 patients were followed up for 5 years,without any case lost to follow-up,and a total of 84 patients had recurrence.The positive expression rates of integrin α5,β1 and β2 in patients with recurrence were higher than those in patients without(P＜0.05).The average survival time and survival rate of patients with positive expression of integrin α5,β1and β2 were shorter/lower than those of patients with negative expression(P＜0.05).Conclusion The positive expression rates of integrin α5,β1and β2 in CRC patients are increased.They are closely related to differentiation degree,TNM stage and lymph node metastasis,and influence postoperative recurrence and survival time of the patients.Therefore,the above indicators can be used for prognosis.
