Expression of PD-1/PD-L1 in lung adenocarcinoma and correlation with epidermal growth factor receptor mutation status
10.3760/cma.j.issn.0529-5807.2016.12.008
- VernacularTitle:不同表皮生长因子受体基因突变状态的肺腺癌中 PD－1／PD－L1的表达
- Author:
Ye WANG
1
,
2
;
Jiping DA
;
Xiuhong WANG
;
Aiping SONG
;
Huang CHEN
;
Honglei ZHANG
;
Sheng CHEN
;
Dewen WANG
Author Information
1. 100850 北京，军事医学科学院放射与辐射医学研究所
2. 中日友好医院病理科
- Keywords:
Lung neoplasms;
Adenocarcinoma;
Receptor,epidermal growth factor;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2016;45(12):854-858
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of programmed cell death-1 ( PD-1 ) and programmed cell death-ligand 1 ( PD-L1 ) in lung adenocarcinoma in correlation with clinical pathological parameters , especially with regard to different epidermal growth factor receptor ( EGFR ) mutation status. Methods One hundred and nine cases of lung adenocarcinoma were collected during the period from Aug . 2010 to Jan. 2016, including 51 cases of EGFR wild type and 58 cases of EGFR mutations. Immunohistochemistry was used to detect PD-1/PD-L1 protein expression. Chi-square test was used to analyze the correlation between PD-1 and PD-L1 expression, and in correlation with clinicopathological parameters.All statistical analyses run by SAS 9.1 software.Results The positive rates of PD-1 and PD-L1 expression were 68.8% ( 75/109 ) and 27.5% ( 30/109 ) , respectively , with significant correlation between the two ( P<0.05 ) .PD-1 and PD-L1 expression rates were higher in 51 cases with EGFR wild type status ( 74.5% and 39.2%) than those in 58 EGFR mutation cases ( 63.8% and 17.2%); PD-1 expression was significantly associated with age ( P <0.05 ); that of PD-L1 was closely correlated with histological type , tumor size , lymph node metastasis and EGFR status ( P<0.05 ) .Conclusions PD-1 and PD-L1 expression profiles and their correlation with EGFR mutations are different from those with native EGFR.PD-L1 overexpression is closely correlated with larger tumor size and lymph node metastasis , suggesting it is a high-grade marker for lung adenocarcinoma .
