MGMT expression in primary central nervous system diffuse large B cell lymphoma and its relationship with prognosis
10.3760/cma.j.issn.0529-5807.2016.12.007
- VernacularTitle:MGMT在中枢神经系统弥漫性大B细胞淋巴瘤中的表达及其预后意义
- Author:
Qianyun SHI
1
;
Xiao FENG
;
Jianjun WANG
;
Xuan WANG
;
Wei BAO
;
Jie MA
;
Qunli SHI
Author Information
1. 210002,南京军区南京总医院病理科/南京医科大学
- Keywords:
Central nervous system neoplasms;
Lymphoma,large B-cell,diffuse;
Prognosis;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2016;45(12):850-853
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between MGMT expression , clinicopathologic features and post-chemotherapy prognosis in patients with primary central nervous system lymphoma diffuse large B-cell lymphoma (PCNS-DLBCL).Methods MGMT expression was detected in 76 cases of PCNS-DLBCL by EnVision method with immunohistochemical staining .Follow-up data including treatment response and overall survival time , were analyzed.Results The rate of MGMT expression in PCNS-DLBCL was 67.1%(51/76).The MGMT expression rate in male patients was higher than that in female (P<0.05). Univariate analysis showed that these clinical pathological characteristics affected the overall survival of PCNS-DLBCL patients , including age and Hans algorithm , although no statistical significance was detected ( P value was 0.065 and 0.069 respectively ) .The overall survival of the patients with positive MGMT and aged over 60 years was shorter after chemotherapy than those without chemotherapy ( P=0.022 ) .In the patients aged over 60 years, the prognosis of MGMT-positive patients was significantly better than MGMT-negative patients ( P=0.044 ) .Conclusions The expression of MGMT is more commonly found in male patients.In the patients aged over 60 years with the same therapy , the prognosis is better in the MGMT-negative ones.Detection of MGMT protein expression can provide some guidance in choice of treatment modalities in PCNS-DLBCL patients.
