The understanding of Epstein-Barr virus associated lymphoproliferative disorder
10.3760/cma.j.issn.0529-5807.2016.12.001
- VernacularTitle:对 EB 病毒相关淋巴组织增殖性疾病的理解和认识对
- Author:
Xiaoge ZHOU
1
;
Yanlin ZHANG
;
Jianlan XIE
;
Yuhua HUANG
;
Yuanyuan ZHENG
;
Wensheng LI
;
Hao CHEN
;
Fang LIU
;
Huaxiong PAN
;
Ping WEI
;
Zhe WANG
;
Yuchang HU
;
Kaiyan YANG
;
Hualiang XIAO
;
Meijuan WU
;
Weihua YIN
;
Kaiyong MEI
;
Gang CHEN
;
Xiaochu YAN
;
Gang MENG
;
Gang XU
;
Juan LI
;
Sufang TIAN
;
Jun ZHU
;
Yuqin SONG
;
Weijing ZHANG
Author Information
1. 100050,首都医科大学附属北京友谊医院病理科
- Keywords:
Lymphoproliferation disorders;
Herpesvirus 4,human
- From:
Chinese Journal of Pathology
2016;45(12):817-821
- CountryChina
- Language:Chinese
-
Abstract:
In recent years , there are increasing articles concerning Epstein-Barr virus associated lymphoproliferative disorder (EBV+LPD), and the name of EBV +LPD is used widely.However,the meaning of EBV+LPD used is not the same , which triggered confusion of the understanding and obstacles of the communication.In order to solve this problem.Literature was reviewed with combination of our cases to clarify the concept of EBV +LPD and to expound our understanding about it .In general, it is currently accepted that EBV +LPD refers to a spectrum of lymphoid tissue diseases with EBV infection , including hyperplasia , borderline lesions , and neoplastic diseases .According to this concept , EBV+LPD should not include infectious mononucleosis ( IM ) and severe acute EBV infection ( EBV +hemophagocytic lymphohistiocytosis, fatal IM, fulminant IM, fulminant T-cell LPD), and should not include the explicitly named EBV+lymphomas ( such as extranodal NK/T cell lymphoma , aggressive NK cell leukemia , Burkitt lymphoma, and Hodgkin lymphoma , etc.) either.EBV +LPD should currently include: ( 1 ) EBV +B cell-LPD:lymphomatoid granulomatosis , EBV +immunodeficiency related LPD , chronic active EBV infection-B cell type, senile EBV +LPD, etc.(2) EBV +T/NK cell-LPD:CAEBV-T/NK cell type, hydroa vacciniforme, hypersensitivity of mosquito bite, etc.In addition, EBV+LPD is classified, based on the disease process , pathological and molecular data , as 3 grades:grade1, hyperplasia ( polymorphic lesions with polyclonal cells ); grade 2, borderline ( polymorphic lesions with clonality ); grade 3, neoplasm (monomorphic lesions with clonality).There are overlaps between EBV +LPD and typical hyperplasia, as well as EBV+LPD and typical lymphomas .However , the most important tasks are clinical vigilance , early identification of potential severe complications , and treating the patients in a timely manner to avoid serious complications , as well as the active treatment to save lives when the complications happened .
