Invasive micropapillary carcinoma of gallbladder:a clinicopathologic study
10.3760/cma.j.issn.0529-5807.2016.11.005
- VernacularTitle:胆囊浸润性微乳头状癌的临床病理特征
- Author:
Jianguo YAO
1
;
Manxiang YIN
;
Chunhua WANG
;
Ying LIU
Author Information
1. 314000,浙江省嘉兴学院附属第二医院 嘉兴二院 病理科
- Keywords:
Gallbladder neoplasms;
Adenocarcinoma;
Carcinoma,papillary
- From:
Chinese Journal of Pathology
2016;45(11):769-773
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicopathologic features of invasive micropapillary carcinoma ( IMPC) of the gallbladder.Methods Among 160 resected cases of gallbladder adenocarcinomas, the clinical and histological features of gallbladder adenocarcinomas with invasive micropapillary components ( IMPC≥5%) were studied.Results The detection rate of IPMC among gallbladder adenocarcinomas was 19.4%(31/160 ).Among these 31 cases, the patients′age ranged from 42 to 84 years ( mean 64.8 years) .The male-to-female ratio was 1∶4.Histologically,19 cases were characterized by small papillary tufts lacking central fibrovascular cores, lying freely within the clefts of fibrous tissue, resembling IMPC of the breast;in five cases, the micropapillary tufts floated within cystic spaces lined by tumor cells, resembling IMPC of the lung;in four cases, slender, delicate filiform processes on the tumor surface with classic IMPC in the depth of gallbladder was observed;and in three cases mixed features were seen.Small cluster invasion ( SCI) was seen adjacent to the IMPC.The lymph node metastatic rate, the lymphovascular invasion rate, and the SCI detection rate were significantly higher in the IMPC group ( P=0.000 ).The IMPC detection rate was related to poorer histological differentiation and increased T stage ( P =0.012, C=0.67; P =0.011,C=0.68).The two-year survival rate of IMPC (4/18) was significantly lower than usual gallbladder carcinoma (54.8%, 23/42).Conclusions Compared to conventional adenocarcinoma of the gallbladder, IMPC has a more advanced tumor status and is prone to lymphovascular invasion and lymph node metastasis, which thus leads to short-term survival.Moreover, SCI may play an important role in the invasion of the IMPC of the gallbladder.
