Therapeutic Plasma Exchange Using the Spectra Optia Cell Separator Compared With the COBE Spectra.
10.3343/alm.2015.35.5.506
- Author:
Do Kyun KIM
1
;
Sinyoung KIM
;
Seok Hoon JEONG
;
Hyun Ok KIM
;
Hyung Jik KIM
Author Information
1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Apheresis;
Plasma exchange;
Kidney transplantation;
Efficacy
- MeSH:
Blood Component Removal;
Graft Rejection;
Humans;
Kidney;
Kidney Transplantation;
Plasma;
Plasma Exchange*;
Plasma Volume;
Retrospective Studies
- From:Annals of Laboratory Medicine
2015;35(5):506-509
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The Spectra Optia (SPO) is a novel continuous-flow centrifugal apheresis system based on the COBE Spectra (CSP) platform. There have been few attempts to validate the advantages of the SPO. We performed a retrospective study comparing the two cell separators for therapeutic plasma exchange (TPE) procedures in kidney transplant (KT) patients and seeing efficacy and safety. METHODS: We analyzed 720 TPE procedures performed between August 2012 and July 2014. Procedures included desensitization TPE before KT and TPE for the management of acute and chronic antibody-mediated graft rejection. Demographic characteristics, operational TPE variables, and laboratory data were analyzed. RESULTS: Demographic characteristics for the SPO (n=389) and CSP (n=331) groups did not differ significantly. The procedure time to exchange one plasma volume was 94.2+/-10.3 min in the SPO group and 100.4+/-11.2 min in the CSP group (P<0.001). The plasma removal efficiency (PRE) was 92.5+/-4.9% in the SPO group and 83.2+/-3.7% in the CSP group (P<0.001). There were no significant differences across the two apheresis systems for changes in hematologic parameters. CONCLUSIONS: Compared with the CSP, the SPO was associated with an improved PRE and a shorter procedure time to exchange one plasma volume. Our results in KT patients show that the SPO is superior to the CSP in TPE procedures.
