Pathology and differential diagnosis of immunotactoid glomerulopathy
10.3760/cma.j.issn.0529-5807.2016.10.007
- VernacularTitle:免疫触须样肾小球病的病理形态观察及鉴别诊断
- Author:
Xiaoling SUN
1
;
Fangcheng ZHANG
;
Yi XIAO
;
Le LIU
;
Yang GUAN
Author Information
1. 430060,武汉大学人民医院超微病理中心
- Keywords:
Kidney diseases;
Microscopy,fluorescence;
Microscopy,electron
- From:
Chinese Journal of Pathology
2016;45(10):703-706
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the morphologic changes of immunotactoid glomerulopathy and to investigate the clinical pathological features and differential diagnosis.Methods Renal biopsy was observed under the light microscope, immunofluorescence and electron microscopy in a case of newly diagnosed immunotactoid glomerulopathy.Results This patient clinically presented with nephrotic syndrome and hypertension, without family history of renal diseases.Light microscopy showed that diffusely massive and specific protein deposition in the glomerulus in Masson staining.Immunofluorescence revealed IgG, C3 andκwere deposited along the capillary walls and mesangial regions.Electron microscopic examination showed that a large amount of microtubule like substances and a small amount of long bar-shaped and dense crystal-like substances were deposited in the subendothelial spaces and mesangial areas.Conclusions Light microscopy and immunofluorescence of immunotactoid glomerulopathy show no specifically pathological changes.Under electron microscope, a large amount of microtubule like substances is deposited in the glomerulus, which is the key point to distinguish this disease from other glomerular diseases.Except for the microtubule-like substances, the present case is accompanied by the deposition of long bar-shaped and dense crystal-like substance, which has not been reported in previous studies.
