The effect of hyperbaric oxygen combined with intravenous thrombolysis on large atherosclerotic stroke and non-large-atherosclerotic-stroke patients and the influencing factors of short-term outcome
10.3969/j.issn.1004-1648.2024.05.006
- VernacularTitle:高压氧联合静脉溶栓治疗大动脉粥样硬化型卒中及非大动脉粥样硬化型卒中患者的效果及短期转归影响因素分析
- Author:
Chunyong HONG
1
;
Qingjin LIN
;
Hua JIANG
Author Information
1. 363000 漳州,中国人民解放军联勤保障部队第九○九医院神经内科
- Keywords:
large atherosclerotic stroke;
hyperbaric oxygen;
erythrocyte distribution width;
white blood cell count/mean platelet volume
- From:
Journal of Clinical Neurology
2024;37(5):345-349
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hyperbaric oxygen combined with intravenous thrombolysis in the treatment of large atherosclerotic stroke(LAA)and non-LAA and the related factors affecting its short-term outcome.Methods One hundred and four patients with acute ischemic stroke of anterior circulation who received hyperbaric oxygen combined with intravenous thrombolysis in our hospital from October 2020 to October 2022 were retrospectively selected.According to TOAST classification,they were divided into LAA group and non-LAA group.The clinical outcome and NIHSS score were compared between the two groups,and the safety of treatment was evaluated.Logistic regression was used to analyze the related factors of short-term outcomes in patients with different etiological types after treatment.Results There were 62 patients in LAA group and 42 patients in non-LAA group.There was no significant difference between the two groups in the baseline data,clinical outcomes,NIHSS scores and safety outcomes(all P＞0.05).Logistic analysis showed that the short-term outcome of patients treated with hyperbaric oxygen combined with intravenous thrombolysis was not related to TOAST classification(P＞0.05),but was related to hypertension,hyperlipidemia,baseline NIHSS score,white blood cell count/mean platelet volume(WMR)and red blood cell distribution width(RDW)(all P＜0.05).Conclusion The efficacy and safety of hyperbaric oxygen combined with intravenous thrombolysis in LAA and non-LAA are comparable,and the short-term outcome after treatment is related to hypertension,hyperlipidemia,baseline NIHSS score,WMR and RDW levels.
