Significance of SATB2 in the pathologic diagnosis of osteosarcoma

VernacularTitle:AT 序列特异性结合蛋白2在骨肉瘤病理诊断中的价值
Author: Ming LI ¹ ; Yongping CAI ; Kangyang LU ; Yong CHEN ; Xia ZHU ; Yu YIN ; Jian TANG
Author Information

1. 安徽医科大学第一附属医院骨科
Keywords: Osteosarcoma; Immunohistochemistry; Special AT-rich sequence-binding protein; Diagnosis,differential
From: Chinese Journal of Pathology 2016;45(9):631-635
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of SATB2 in the pathological diagnosis and differential diagnosis of osteosarcoma.Methods Immunostaining of SATB2 was performed in 47 cases of osteosarcomas, 5 osteoblastomas, 4 fibrous dysplasias, 5 myositis ossificans, 10 chondroblastomas, 8 chondrosarcomas, 5 Ewing sarcomas, 5 undifferentiated pleomorphic sarcomas, 6 fibrosarcomas and 2 leiomyosarcomas.Results All osteoblastomas (5/5) and myositis ossificans (5/5), 83.0%(39/47) of osteosarcomas and 2/10 of chondroblastomas showed nuclear immunoreactivity for SATB2.SATB2 staining was negative in all cases of fibrous dysplasia, chondrosarcomas, Ewing sarcomas and all bone primary spindle cell sarcomas ( undifferentiated pleomorphic sarcoma, fibrosarcoma and leiomyosarcoma ) .Conclusion SATB2 is a reliable osteoblastic marker for differential diagnosis of osteosarcoma and non-osteoid sarcoma, although with a limited role in separating osteosarcoma from non-malignant osteoblastic lesions.