Research progress of gut microbiota and Alzheimer's disease

VernacularTitle:肠道菌群与Alzheimer's病的研究进展
Author: Changsheng QIU ¹ ; Ting WU
Author Information

1. 210029 南京医科大学第一附属医院神经内科
Keywords: Alzheimer's disease; gut microbiota; pathomechanism; new therapy
From: Journal of Clinical Neurology 2024;37(4):304-307
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is a degenerative disease of CNS that tends to occur in the elderly.It is characterized by cognitive decline and memory impairment,accompanied by mental symptoms,which seriously affect the daily life of patients.The gut microbiota is a collection of all microorganisms residing in the gastrointestinal tract(GI)and is an integral part of the human body.The gut microbiota can affect the CNS through the brain-gut axis,thereby increasing the risk of the occurrence of AD.The traditional drugs approved for AD are not effective,so a new treatment for AD is urgently needed.This paper will explain the relationship between intestinal flora and AD,and explore new therapies for AD targeting intestinal flora.