ARID1A expression of SWI/SNF remodeling complex in pancreatic neuroendocrine tumor
10.3760/cma.j.issn.0529-5807.2016.08.015
- VernacularTitle:SWI/SNF染色质重塑复合体组分ARID1A在胰腺神经内分泌肿瘤中的表达
- Author:
Li ZHANG
1
;
Congwei JIA
;
Zhaohui LU
;
Jie CHEN
Author Information
1. 100730,中国医学科学院 北京协和医学院 北京协和医院病理科
- Keywords:
Pancreatic neoplasms;
Neuroendocrine tumors;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2016;45(8):571-574
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study ARID1A expression and its role in pancreatic neuroendocrine tumors.Methods 51 cases of pancreatic neuroendocrine tumors were collected from July 2003 to May 2012 from Peking Union Medical College Hospital.Eighteen normal pancreatic tissues were used as positive control.HE staining method was used to observe general clinicopathological features.ARID1A expression was detected immunohistochemically by EnVision method.The relationship between ARID1A expression and tumor grade and stage was analyzed.Results The level of ARID1A expression was not associated with patients' gender,age,TNM stage,and tumor size (P ＞ 0.05);but showed significantly negative correlation with tumor grade (P ＜ 0.05).Conclusions Low ARID1A expression was significantly related to the high grade level of pancreatic neuroendocrine tumors.It has a certain effect on the clinical classification of pancreatic neuroendocring tumors.ARID1A may play a role as a tumor suppressor gene.
