Myelin oligodendrocyte glycoprotein antibody-related diseases with onset with spinal cord injury(report of 2 cases)
10.3969/j.issn.1004-1648.2024.04.014
- VernacularTitle:以脊髓损害为首发症状的髓鞘少突胶质细胞糖蛋白抗体相关性疾病(附2例报道)
- Author:
Xiao XIAO
1
;
Jihong TANG
;
Bingbing ZHANG
Author Information
1. 215025 苏州大学附属儿童医院神经内科
- Keywords:
myelin oligodendrocyte glycoprotein antibody associated disorders;
spinal injury;
treatment
- From:
Journal of Clinical Neurology
2024;37(4):283-286
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and immunotherapy effect of myelin oligodendrocyte glycoprotein antibody(MOG-Ab)-associated disorders(MOGAD)onset with spinal cord injury.Methods Clinical data of 2 children with MOGAD onset with spinal cord injury were retrospectively analyzed.Results The first symptoms of 2 children were both lower limbs fatigue.After testing the full-length MOG-Ab in both serum and CSF and MRI scanning,they were diagnosed as MOGAD onset with spinal cord injury.The clinical symptoms were relieved after hormone impact treatment,and the range of abnormal signals were reduced by reexamination.After discharge,the patient was followed up for more than 5 months,and the clinical symptoms were cured without recurrence.Conclusions MOGAD onset with spinal cord injury is a rare disease type.Its early clinical manifestations may be neck,back and waist discomfort,gradually aggravated limb weakness,urination and defecation dysfunction.Imaging examination shows abnormal signals of multi-segmental spinal cord,and MOG-Ab could be detected in CSF and peripheral blood.Early identification and diagnosis and timely application of hormone impact treatment can help to quickly relieve clinical symptoms and improve prognosis.
