Eccrine angiomatous hamartoma:a clinicalopathologic analysis of 4 cases
10.3760/cma.j.issn.0529-5807.2016.07.008
- VernacularTitle:小汗腺血管瘤样错构瘤临床病理观察
- Author:
Xiaohong GUO
1
;
Genyuan YANG
;
Chubin LI
;
Lijuan WANG
;
Jie ZHANG
;
Xiujuan YUAN
Author Information
1. 519000,广东省珠海市人民医院病理科
- Keywords:
Eccrine glands;
Hamartoma;
Immunohistochemistry;
Diagnosis,differential
- From:
Chinese Journal of Pathology
2016;45(7):467-471
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and histopathologic features , diagnosis and differential diagnosis of eccrine angiomatous hamartoma ( EAH ).Methods Four cases of eccrine angiomatous hamartoma were studied by light microscopy and immunohistochemical staining along with review of the literature.Results There were 3 male and 1 female patients at diagnosis in age of 4 months, 3.5 years, 5.5 years and 14.0 years, respectively.Tumor sites included the left little finger (1 case), right index finger (1 case), lower back (1 case) and knee (1 case).Clinically, most cases presented as a solitary, flesh or reddish papule , plaque or nodule with size of 0.4-6.0 cm in diameter.The skin lesions in 3 cases enlarged commensurate with the growth of the patients , and local hyperhidrosis in one case.Histologically, EAH was characterized by proliferation of well-differentiated eccrine secretory and ductal elements closely associated with thin-walled angiomatous channels in the middle or deep dermis and subcutaneous tissue.By immunohistochemistry , the vascular components were positive for CD 31, CD34 and factorⅧrelated antigen while the eccrine glands were positive for S-100 protein, CEA, EMA, CAM5.2 and GCDFP15.Local surgical resection was performed in 4 cases and follow-up data (0.5 to 4.5 years) showed no recurrence.Conclusion EAH is a rare, benign cutaneous hamartoma.Combination of clinical manifestations , histological changes and immunohistochemical findings is useful for the diagnosis and differential diagnosis .
