Research progress of the correlation between cerebral white matter hyperintensity and cognitive ability
10.3969/j.issn.1004-1648.2024.03.021
- VernacularTitle:脑白质高信号与认知功能相关性的研究进展
- Author:
Teng ZHANG
1
;
Suxin YANG
;
Yidan YAN
Author Information
1. 225002 扬州大学附属医院神经内科
- Keywords:
white matter hyperintensity;
cognitive impairment;
dementia;
neuroimaging
- From:
Journal of Clinical Neurology
2024;37(3):226-230
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral white matter hyperintensity(WMH)is a type of ischemic alteration that appears as speckled or patchy areas around the ventricles and in the centrocentral area of the semiovals.This alteration can be caused by various factors and indicates a change in the composition of the white matter in the brain.It suggests an alteration in the water content of the hydrophobic white matter fiber bundles.WMH is commonly used as an imaging marker for cerebral small vessel disease.Previous studies have shown that WMH is highly correlated with cognitive impairment.Large-scale longitudinal studies,both population-based and hospital-based,have confirmed the correlation between WMH and clinical symptoms and demonstrated a causal relationship between large-scale WMH and dementia.Adequate differential diagnosis,evaluation,and management are crucial for patients,especially those with early cognitive impairment.Novel imaging techniques may detect subtle impairments before they become visible on an MRI.The purpose of this review is to offer a comprehensive overview of the relationship between WMH and cognitive function.
