Association between polymorphism in Vav3 genes and risk of primary prostatic cancer in Chinese Han population
10.3760/cma.j.issn.0529-5807.2016.07.005
- VernacularTitle:Vav3基因位点多态性与中国汉族人群前列腺癌发病风险的关联性
- Author:
Ming LIU
1
;
Na MIAO
;
Yao ZHU
;
Chengyuan GU
;
Xiaoli SHI
;
Wenli CUI
;
Wei ZHANG
;
Qiaoxin LI
Author Information
1. 新疆医科大学第一附属医院病理科
- Keywords:
Prostatic neoplasms;
Genetic predisposition to disease;
Polymorphism,single nucleotide
- From:
Chinese Journal of Pathology
2016;45(7):451-456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the associations between genetic variations of Vav 3 gene and prostate cancer susceptibility.Methods Data were collected in a hospital-based and case-control study of 1 015 prostate cancer cases and 1 068 cancer-free controls collecting from a period of time between 2008 and 2012.Based on the online database , NCBI dbSNP ( http://www.ncbi.nlm.nih.gov/projects/SNP ) and SNPinfo ( http://snpinfo.niehs.nih.gov/snpfunc.htm ) . Functional single nucleotide polymorphisms (SNPs) of Vav3 were screened and genotyped , and assessed their associations with risk of prostate cancer by using logistic regression analysis.Furthermore, the associations between SNPs of Vav 3 and some clinicopathological parameters were evaluated.Results Among the two SNPs investigated , only Vav3 rs12410676 G>A was associated with decreased prostate cancer risk [additive model, OR=0.80 (0.69-0.93), P=0.003;dominant model, OR=0.81 (0.68-0.97), P=0.022;recessive model, OR=0.54 (0.36-0.82), P=0.004].The combined effect of Vav3 rs8676 G>A and rs12410676 G>A was found as a decreased prostate cancer risk along with the increased variant alleles ( P <0.05 ).Specifically , participants carrying Vav 3 rs12410676 AA/AG genotypes were more likely to be at lower prostate cancer risk, compared with participants carrying GG genotypes , in groups of BMI≤25 kg/m2 , smoking, Gleason>7(4+3), and higher invasive prostate cancer .Finally, some positive findings were evidently significant with false positive report probability values at different prior probability levels (0.25,0.1 and 0.01).Conclusion Vav3 SNPs may contribute to the risk of prostate cancer in Eastern Chinese men , but the effect is weak and needs further validation by larger , multicenter and ethnic-based studies.
