Application of target-specific repeated transcranial magnetic stimulation in mild cognitive impairment and relevant brain network basis

VernacularTitle:基于特定靶点的重复经颅磁刺激在轻度认知功能障碍的应用及其脑网络基础
Author: Rui MAO ¹ ; Zhiyuan YANG ; Yun XU
Author Information

1. 210008 南京大学医学院附属鼓楼医院神经内科
Keywords: mild cognitive impairment; repetitive transcranial magnetic stimulation; brain network
From: Journal of Clinical Neurology 2024;37(3):217-221
CountryChina
Language:Chinese
Abstract: Mild cognitive impairment(MCI)is an intermediate state between normal aging and dementia,and there is a risk of conversion to dementia if left untreated.Repetitive transcranial magnetic stimulation(rTMS)is a physical treatment for neuropsychiatric disorders that noninvasively acts on target area to upregulate neurotrophic substance expression,modulate cortical physiological activity,affect regional connectivity,and induce synaptic plasticity.On this basis,rTMS can realize targeted-regulation of damaged neural circuits,thereby improving cognitive dysfunction and becoming an effective method to intervene in MCI.This paper summarizes the theoretical background of this technology and further discusses the brain network that may be affected by target-specific rTMS in ameliorating MCI,in order to provide reference for clinical translation.