Patients with prostatic cancer undergoing radical prostatectomy after single positive core biopsy:a clinicopathologic analysis of 62 cases
10.3760/cma.j.issn.0529-5807.2016.07.004
- VernacularTitle:穿刺单针阳性前列腺癌患者根治术后62例临床病理分析
- Author:
Shaojing DU
1
;
Huiying HE
Author Information
1. 100191,北京大学医学部基础医学院病理系 北京大学第三医院病理科
- Keywords:
Prostatic neoplasms;
Punctures;
Neoplasm staging
- From:
Chinese Journal of Pathology
2016;45(7):446-450
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical and pathological features of patients with prostate cancer who had only one positive biopsy core and underwent radical prostatectomy ( RP).Methods A total of 62 patients with prostate cancer who had only one positive biopsy core and underwent RP were enrolled .The clinicopathological features of the biopsy and RP were analyzed.Those factors that may cause discordance of Gleason score ( GS ) and influence pathological T ( pT ) stage on RP were further evaluated.Results Out of the 62 patients, 40 ( 64.5%) had pT stage ≥pT2c.The positive surgical margins, extraprostatic extension and seminal vesicle invasion were found in 17.7%( 11/62 ), 9.7%(6/62) and 3.2%(2/62) of patients, respectively.Compared to GS of RP, that of biopsy specimens was concordant in 39 ( 62.9%) , higher in 6 ( 9.7%) , and lower in 17 ( 27.4%) patients.There was no significant correlation between GS discordance and age , preoperative PSA level , FPSA/TPSA or maximum percentage of cancer per core (P>0.05).The maximum percentage of cancer per core (χ2 =6.670 7,P=0.009 8) and biopsy GS (χ2 =4.020 0, P =0.045 0 ) were significantly related to the pT stage on RP.Conclusions Single positive core prostate cancer at biopsy should not be considered as a low-risk disease.Although the preoperative clinicopathological factors cannot predict lower GS on biopsy , the maximum percentage of cancer per core and GS on biopsy are of significance to the pT stage on RP .
