Clinical features of antineutrophil cytoplasmic antibody-associated vasculitis with peripheral neuropathy as the initial symptom
10.3969/j.issn.1004-1648.2024.03.012
- VernacularTitle:以周围神经病为首发症状的抗中性粒细胞胞浆抗体相关性血管炎的临床特点
- Author:
Yuqin ZHANG
1
;
Hailing TONG
;
Chen HOU
Author Information
1. 410000 长沙,中南大学湘雅医院全科医学科
- Keywords:
antineutrophil cytoplasmic antibody-associated vasculitis;
peripheral neuropathy;
autoimmune disease
- From:
Journal of Clinical Neurology
2024;37(3):197-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of antineutrophil cytoplasmic antibody(ANCA)-associated vasculitis(AAV)with peripheral neuropathy as the initial symptom and to enhance the understanding of the disease.Methods The clinical data of 6 patients of AAV with peripheral neuropathy as the initial symptom at Xiangya Hospital of Central South University from 2017 to 2021 were collected.Results All 6 cases were middle-aged or elderly males,and the initial symptoms mainly consisted of limb numbness,pain,and weakness.In addition to neurological involvement,some patients had upper respiratory tract,lungs,kidneys,eyes,ears,skin and joints involved.Electromyography showed multiple peripheral nerve damage;Five patients were positive for pANCA and MPO,and one patient was positive for cANCA and PR3.Six patients were all treated with glucocorticoid and cyclophosphamide,and the clinical symptoms and laboratory indexes were improved to different degrees.Conclusions There were no characteristic symptoms in AAV with peripheral neuropathy as the first symptom.Early diagnosis and treatment of AAV can improve the quality of life and prognosis of patients.
