Relationship between the expression of regulators of G-protein signalling 2 in brain tissue around hematoma and inflammatory response,short-term prognosis of patients with hypertensive intracerebral hemorrhage
10.3969/j.issn.1004-1648.2024.03.010
- VernacularTitle:血肿周围脑组织中G蛋白信号调节因子2表达水平与高血压脑出血患者炎症反应及短期预后的关系
- Author:
Yanpeng YAO
1
;
Dongdong CAO
;
Lichao LI
Author Information
1. 744000 平凉,甘肃医学院附属医院神经外科
- Keywords:
hypertensive cerebral hemorrhage;
regulators of G-protein signaling 2;
inflammatory response;
short term prognosis;
influencing factors;
predictive value
- From:
Journal of Clinical Neurology
2024;37(3):188-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the expression level of regulators of G-protein signalling 2(RGS2)in brain tissue around hematoma and inflammatory response,short-term prognosis of patients with hypertensive intracerebral hemorrhage.Methods A total of 124 patients with hypertensive intracerebral hemorrhage who underwent hematoma clearance in our hospital from May 2019 to May 2022 were selected as the cerebral hemorrhage group,22 patients with non cerebral hemorrhage who underwent autopsy were selected as the control group.The protein expression of RGS2,TNF-α,IL-1β were detected.The mRS scores of patients with intracerebral hemorrhage at 3 months after discharge were evaluated,patients were divided into patients with good prognosis and patients with poor prognosis.Pearson test was used to analyze correlation between RGS2 and TNF-α,IL-1β.Logistic regression was used to analyze the influencing factors of the short-term prognosis of patients with cerebral hemorrhage,ROC curve was used to analyze the predictive value of RGS2,TNF-α,IL-1β for the short-term prognosis of patients with cerebral hemorrhage.Results The relative expression level of RGS2 protein in brain tissue around hematoma of cerebral hemorrhage group was lower than that in control group,the relative expression level of TNF-α,IL-1β were higher than those of the control group(all P<0.05).There was a negative correlation between the relative expression level of RGS2 and TNF-α,IL-1β.The NIHSS score,random blood glucose level,cerebral hemorrhage volume and the relative expression level of TNF-α,IL-1β of patients with poor prognosis in the cerebral hemorrhage group were higher than those of patients with good prognosis,and the relative expression level of RGS2 was lower than that of patients with good prognosis(all P<0.05).Logistic regression analysis showed that NIHSS score,hematoma volume and the relative expression level of RGS2,TNF-α,IL-1β were influencing factors of the short-term prognosis of patients with cerebral hemorrhage.ROC curve analysis showed that the relative expression level of RGS2,TNF-α,IL-1β had predictive value for the short-term prognosis of patients with cerebral hemorrhage.Conclusion The decreased expression of RGS2 in the brain tissue around the hematoma of hypertensive intracerebral hemorrhage is related to the activation of inflammatory reaction and poor short-term prognosis.
