Research progress on energy metabolism changes in frail patients and perioperative interventions
- VernacularTitle:衰弱患者能量代谢改变及围术期干预的研究进展
- Author:
Xiangting LI
1
;
Ling LIN
;
Qiqing SHI
Author Information
- Keywords: Frailty; Glucose metabolism; Fat metabolism; Amino acid metabolism; Perioperative period
- From: The Journal of Clinical Anesthesiology 2024;40(11):1214-1217
- CountryChina
- Language:Chinese
- Abstract: Frailty is a clinical syndrome characterized by the gradual decline of multiple organ func-tion and the emergence of vulnerable phenotype.Patients with frailty exhibit diminished resistance to stress,which often leads to unfavorable outcomes following surgery,including cognitive decline,prolonged hospital-ization,and increased rates of complications and mortality.Given that frailty is a dynamic and reversible process,it is recommended to implement appropriate optimization measures during the perioperative period in order to improve patient outcomes.Recent studies have revealed that abnormal energy metabolism plays a crucial role in the development and occurrence of frailty.This article will primarily focus on abnormalities in glucose metabolism,lipid metabolism,and amino acid metabolism among frail patients,and emphasize the significance of correcting these metabolic irregularities during the perioperative period in order to reduce complications and improving surgical safety.
