Clinicopathologic features of inflammatory fibroid polyp in gastrointestinal tract
- VernacularTitle:胃肠道炎性纤维性息肉的临床病理分析
- Author:
Jianguo WEI
1
;
Chunwei XU
;
Bo ZHANG
;
Aijing SUN
Author Information
1. 312000,浙江省绍兴市人民医院病理科
- Keywords:
Gastrointestinal diseases;
Intestinal polyps;
Diagnosis,differential;
Immunophenotyping
- From:
Chinese Journal of Pathology
2015;(10):714-718
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicopathologic characteristics , immunophenotypes , pathologic diagnosis and differential diagnosis of gastrointestinal inflammatory fibroid polyp ( IFP) .Methods The clinical data, histologic features and immunohistochemical results of 6 cases of gastrointestinal inflammatory fibroid polyp were analyzed , with review of literature.Results There were altogether 5 women and a man.The age of patients ranged from 44 to 87 years ( median age =61 years and mean age =62 years).The sites of involvement included stomach (number=2), jejunum (number=2), distal ileum ( number=1 ) and rectum ( number =1 ) .The patients often presented with abdominal pain or discomfort and tarry stool.All the cases studied showed similar morphology , were submucosa-based and composed of bland spindle cells associated with loose collagenous stroma and perivascular edema .Prominent concentric fibroblastic proliferation (“onion-skin” appearance ) and eosinophilic infiltrate were characteristics .Three of the patients underwent surgical resection .The remaining patients had the lesions removed with endoscopy . Follow-up data were available in 5 patients and none of them had disease recurrence or metastasis . Conclusions IFP is a rare benign tumor of gastrointestinal tract .Correct diagnosis primarily relies on pathologic examination .It needs to be distinguished from gastrointestinal stromal tumors or inflammatory myofibroblastic tumor .