Progress on the anesthetics affecting mitochondrial quality in tissue cells
- VernacularTitle:麻醉药物对组织细胞线粒体质量影响的研究进展
- Author:
Xuxin TAN
1
;
Ruixue LIU
;
Ling DAN
;
He HUANG
;
Chenyang DUAN
Author Information
- Keywords: Anesthetics; Mitochondrial quality; Organ function; Clinical outcome
- From: The Journal of Clinical Anesthesiology 2024;40(10):1105-1109
- CountryChina
- Language:Chinese
- Abstract: In recent years,researchers have shown widespread attention in the impact of commonly used clinical anesthetics on overall physiological health by influencing mitochondrial quality.These widely used anesthetics can alter mitochondrial characteristics in several ways,such as modifying mitochondrial morphology and dynamics,affecting mitochondrial function and metabolism,and altering the expression of mitochondrial proteins.These changes have a direct or indirect effect on clinical outcomes during the peri-operative period.Either beneficial or detrimental consequences are decided by multiple factors,such as the type and dosage of anesthetic used,the timing of administration,and the patient's condition.This review comprehensively presents the effects of different types of anesthetic drugs,including intravenous anesthetics,inhalational anesthetics,analgesic,and local anesthetics,on the mitochondria quality of tissue cells and their potential mechanisms,which can facilitate selecting safer anesthesia protocols,minimizing postoperative complications,optimizing patients'postoperative recovery,developing new therapeutic strategies,and opti-mizing perioperative management.
