Research progress of microRNA involved in perioperative neurocognitive disorders regulation
- VernacularTitle:微小RNA参与调控围术期神经认知障碍的研究进展
- Author:
Junlin LIU
1
;
Yi LI
;
Wenjie LIU
Author Information
- Keywords: MicroRNA; Perioperative neurocognitive disorders; Neuroinflammation; Pain
- From: The Journal of Clinical Anesthesiology 2024;40(10):1079-1084
- CountryChina
- Language:Chinese
- Abstract: Perioperative neurocognitive disorders(PND)is one of the common complications in the perioperative period,especially in elderly patients,and the incidence of PND is high and it is closely related to the prognosis of surgery.The currently accepted pathogenesis of PND includes central nervous sys-tem inflammation,synaptic dysfunction,apoptosis,oxidative stress,and neurofibrillary tangles,etc.Mi-croRNAs(miRNAs),as key gene expression regulators of neurological development and function,are not only directly involved in these processes,but also indirectly affect PND development through the modulation of the microbiota-gut-brain axis,perioperative mood regulation,and postoperative pain.In this paper,we review the role of miRNA in regulating perioperative neurocognitive disorders,with the aim of providing new ideas for the diagnosis and prevention of PND,as well as for the development of targeted therapies for this disease.
