Correlation of Twist and YB-1 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma
10.3760/cma.j.issn.0529-5807.2015.08.010
- VernacularTitle:Twist 及 YB-1基因表达上调与子宫颈癌上皮间质转化的相关性
- Author:
Min LI
1
;
Hong GUAN
;
Xinrong HU
;
Ying WANG
;
Qian WEI
;
Qingfeng YANG
Author Information
1. 518109,广东省深圳市龙华新区人民医院病理科
- Keywords:
Twist transcription factor;
Epithelial-mesenchymal transition;
Uterine cervical neoplasms;
YB-1;
E-cadherin
- From:
Chinese Journal of Pathology
2015;(8):594-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological significance of Twist and YB-1 up-regulation in cervical cancer , and to correlate the expression of the two genes with E-cadherin , a marker of epithelial-mesenchymal transition ( EMT).Methods A total of 202 tissue samples were collected during January 2008 to December 2013, including 50 cases of normal cervical tissues , 100 cases of cervical intraepithelial neoplasia ( CIN ) and 52 cases of squamous cell carcinoma ( SCC ).Twist, YB-1 and E-cadherin expression was investigated by MaxVision .Results Increased expression levels of Twist and YB-1 were found and correlated with the malignant transformation of cervical epithelium , histological progression and metastasis of cervical cancer.In addition, Twist and YB-1 overexpression was also associated with aberrant expression of E-cadherin.Regression analysis revealed that Twist expression was an independent factor for the histological progression of cervical cancer.Conclusions It is suggested that Twist and YB-1 overexpression is significantly linked to cervical cancer tumorigenesis and progression , likely related to EMT through ( YB-1 )-Twist-( E-cadherin ) pathway.Twist and YB-1 may be markers for determining the metastatic potential of cervical cancer.
