Diagnostic value of MYB protein expression in adenoid cystic carcinoma and status of MYB gene copy number
10.3760/cma.j.issn.0529-5807.2015.08.008
- VernacularTitle:MYB 蛋白表达在腺样囊性癌诊断中的意义及 MYB 基因拷贝数状况
- Author:
Zhen HUO
1
;
Xuan ZENG
;
Shafei WU
;
Huanwen WU
;
Yunxiao MENG
;
Yuanyuan LIU
;
Yufeng LUO
;
Jinling CAO
;
Zhiyong LIANG
Author Information
1. 100730,中国医学科学院 北京协和医学院 北京协和医院病理科
- Keywords:
Carcinoma,adenoid cystic;
Salivary gland neoplasms;
Immunohistochemistry;
In situ hybridization,fluorescence
- From:
Chinese Journal of Pathology
2015;(8):582-586
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of MYB protein expression for adenoid cystic carcinoma and its differential diagnosis from other salivary gland tumors ,and to further investigate the status of MYB gene copy number .Methods MYB expression was studied by immunohistochemistry in 34 adenoid cystic carcinomas , 55 non-adenoid cystic carcinomas ( other salivary gland tumors ) including 10 pleomorphic adenomas, 10 basal cell adenomas , 10 epithelial-myoepithelial carcinomas , 9 basal cell adenocarcinomas , 8 mucoepidermoid carcinomas , 4 carcinoma in pleomorphic adenomas , and 4 polymorphous low-grade adenocarcinoma.MYB gene copy number status was detected by FISH in MYB protein-positive cases.Results 82.4%(28/34) of adenoid cystic carcinomas were MYB protein-positive, compared with 9.1%(5/55) of non-adenoid cystic carcinomas, and the difference between the two groups was statistically significant ( P<0.01).2/18 of adenoid cystic carcinomas had duplication of MYB gene by FISH , and all non-adenoid cystic carcinomas were negative although the difference was not statistically significant ( P=0.435).Conclusions MYB protein expression is a useful diagnostic marker for adenoid cystic carcinomas in its separation from other salivary gland tumors.In addition , duplication of MYB gene is no a major mechanism for the MYB protein overexpression .
