Diagnostic value of SATB2, CK7 and CK20 in colorectal cancer

VernacularTitle:联合检测 SATB2、CK20和 CK7对结直肠癌病理诊断的价值
Author: Jinghuan LYN ¹ ; Yanfen WANG ; Feng WANG ; Minghong SHEN ; Xiaojun ZHOU
Author Information

1. 210002,南京大学医学院附属金陵医院南京军区南京总医院病理科
Keywords: Colorectal neoplasms; SATB2; CK7; CK20
From: Chinese Journal of Pathology 2015;(8):578-581
CountryChina
Language:Chinese
Abstract: Objective To study the diagnostic value of SATB2, together with CK7 and CK20, in colorectal cancer.Methods Immunohistochemical study for SATB 2, CK7 and CK20 was carried out in 210 cases of colorectal cancer tissue , 100 cases of non-colorectal cancer tissue , 90 cases of lymph node metastases and 50 cases of normal colorectal mucosa .Results The sensitivity and specificity of CK 20+/CK7-immunophenotype for diagnosis of colorectal adenocarcinoma were 78.1%and 92.0%, respectively.When triple markers were used , the immunophenotype CK 20 +/CK7 -/SATB2 +had a sensitivity of 57.1% and a specificity of 98.0%. When combining the immunophenotype of SATB 2 +/CK7 -or CK20+/CK7-, the sensitivity was 85.7% and specificity was 90.0%.Conclusions A panel of immunohistochemical markers SATB 2, CK7 and CK20 could increase the specificity for diagnosis of colorectal adenocarcinoma significantly.SATB2 is considered as a useful adjunct in this respect.