Clinicopathologic analysis of angioimmunoblastic T-cell lymphoma with Hodgkin/Reed-Sternberg-like cells
10.3760/cma.j.issn.0529-5807.2015.08.003
- VernacularTitle:血管免疫母细胞性T细胞淋巴瘤伴霍奇金样细胞的临床病理分析
- Author:
Xue GAO
1
,
2
;
Wenyong HUANG
;
Wensheng LI
;
Jianlan XIE
;
Yuanyuan ZHENG
;
Xiaoge ZHOU
Author Information
1. 100050 首都医科大学附属北京友谊医院病理科
2. 大连医科大学附属第一医院病理科
- Keywords:
Lymphoma,T-cell;
Herpesvirus 4,human;
Immunophenotyping
- From:
Chinese Journal of Pathology
2015;(8):553-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicopathologic features and pathologic diagnosis and differential diagnosis of angioimmunoblastic T-cell lymphoma with HRS-like cells.Methods Six cases of angioimmunoblastic T-cell lymphoma with HRS-like cells were examined histologically and immunohistochemically ( EliVision method ) and in-situ hybridization for Epstein-Barr virus-encoded RNA (EBER), and the literature was reviewed.Results The cytologic and microscopic features of these imprints and lymph node samples showed a heterogeneous population of hematolymphoid cells , including small to intermediate lymphoid cells, immunoblasts, plasma cells, dendritic cells, and eosinophils, as well as small vessels that were surrounded by some of the abnormal cells.The neoplastic T-cells expressed CD3 and CD5 and partly positive for CD10 and bcl-6, CD21 showed expanded and irregular follicular dendritic cell ( FDC) meshworks that surrounding the high HEV.The HRS-like cells were positive for MUM-1 and Ki-67, variable intensity positive for CD30, CD20, and PAX-5, but negative for CD15.EBV-positive cells included HRS-like cells and small to large-sized neoplastic T-cells, which formed small clusters or scattering in the background of the disease.Conclusions The clinical course of angioimmunoblastic T-cell lymphoma with HRS-like cells is aggressive.Which present with histomorphology overlap with classical Hodgkin lymphoma ( CHL) , similar to CHL in EBER and immunophenotype , however, it is easy to misdiagnosis as HL.Thus, angioimmunoblastic T-cell lymphoma pathology diagnosis should comprehensive analysis of different kinds of materials , including clinical features , and histological structure , and EBER , and immunophenotype , and gene rearrangement .
