Clinicopathologic analysis of HIV-negative plasmablastic lymphoma
10.3760/cma.j.issn.0529-5807.2015.08.002
- VernacularTitle:人免疫缺陷病毒阴性的浆母细胞性淋巴瘤临床病理观察
- Author:
Yu CHEN
1
,
2
;
Yanhui LIU
;
Donglan LUO
;
Fen ZHANG
;
Fangping XU
;
Yan GE
;
Xinlan LUO
;
Jie CHEN
Author Information
1. 510080 广州，广东省人民医院 广东省医学科学院 病理科
2. 汕头大学医学院
- Keywords:
Lymphoma;
Herpesvirus 4,human;
Diagnosis,differential;
Prognosis
- From:
Chinese Journal of Pathology
2015;(8):548-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical, pathologic, immunophenotype, molecular characteristics and prognosis of HIV-negative plasmablastic lymphoma ( PBL ).Methods Twelve cases of HIV-negative PBLs diagnosed between 2005 and 2014 in Guangdong General Hospital were identified according to WHO classification of tumors of haematopoietic and lymphoid tissues ( 2008 ) .The clinicopathologic features and outcome were analyzed and the relevant literatures were reviewed .Results The patients were predominantly male (11/12) with a median age of 55.5 years.The tumor cells showed the characteristic combination of immunoblastic/plasmablastic morphology , plasma cell phenotype and high proliferation, no expression of mature B cell markers.7/10 of the cases were EBER positive.Two cases were positive for C-myc translocation.Four of twelve patients were died.Conclusions PBL is a rare, aggressive B-cell lymphoma.HIV-negative PBL has lower rate of oral involvement and EBER expression than HIV -positive patients ,the differential diagnosis is very challenging ,and the prognosis is worse.
