Diagnosis value of TTF-1,Napsin A and Ki-67 index in primary salivary gland-type lung carcinomas
10.3760/cma.j.issn.0529-5807.2015.07.017
- VernacularTitle:甲状腺转录因子1、胃酶样天冬氨酸蛋白酶及 Ki-67在肺原发唾液腺型癌中的鉴别诊断价值
- Author:
Binglin ZHANG
1
;
Jie LIN
;
Jiping DA
Author Information
1. 中日友好医院病理科
- Keywords:
Lung neoplasms;
Immunohistochemistry;
Diagnosis,differential
- From:
Chinese Journal of Pathology
2015;(7):499-503
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicopathologic characteristics of primary salivary gland-type lung carcinomas, and the immunophenotypic value of TTF-1, Napsin A and Ki-67 in their differential diagnosis.Methods Totally 48 special type lung cancer surgical removal specimens were collected in China-Japan Friendship Hospital during September 2009 to December 2014. A panel of immunohistochemical markers (TTF-1,Napsin A,Ki-67,CK5/6,CK7 and p63) were conducted on these specimens.Results The 48 cases of special type lung cancer included 25 cases of primary salivary gland-type lung carcinoma ( 18 cases of adenoid cystic carcinoma and 7 cases of mucoepidermoid carcinoma ) , 5 cases pulmonary adenocarcinoma with mucoepidermoid carcinoma-like or adenoid cystic carcinoma-like structure,and 18 cases of pulmonary adenosquamous carcinoma.Compared with pulmonary adenocarcinoma with mucoepidermoid carcinoma-like or adenoid cystic carcinoma-like structure and pulmonary adenosquamous carcinoma , primary salivary gland-type lung carcinomas have special characteristics in median age, sex, location, tumor size, LN involvement and pleura invasion , with negative TTF-1 and Napsin A expression as well as lower Ki-67 index detected by immunohistochemistry.Primary salivary gland-type lung carcinomas usually have an indolent behavior.Conclusions Primary salivary gland-type lung carcinomas are low-aggressive entities.The origins of primary salivary gland-type lung carcinomas were different from that of pulmonary adenocarcinoma with mucoepidermoid carcinoma-like or adenoid cystic carcinoma-like structure and pulmonary adenosquamous carcinoma.Negative TTF-1 and Napsin A expression as well as Ki-67 index lower than 20%have special value for primary salivary gland-type lung carcinomas in their differential diagnosis.
