Epithelioid hemangioendothelioma:a clinicopathologic analysis of 13 cases
10.3760/cma.j.issn.0529-5807.2015.06.005
- VernacularTitle:上皮样血管内皮瘤13例临床病理分析
- Author:
Hai LI
1
;
Cong WANG
;
Yan ZHU
;
Hongxia LI
;
Zhihong ZHANG
;
Qinhe FAN
Author Information
1. 210029,南京医科大学第一附属医院病理科
- Keywords:
Hemangioendothelioma,epithelioid;
Immunohistochemistry;
Diagnosis,differential
- From:
Chinese Journal of Pathology
2015;(6):386-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathologic characteristics of epithelioid hemangioendothelioma ( EHE) .Methods Thirteen cases of EHE were analyzed by gross examination, light microscopy and immunohistochemical staining.Results The patients included 6 males and 7 females.The age of patients ranged from 11 to 74 years ( mean=43 years) .The tumors were located in soft tissue, liver, lung, mediastinum, sacrum, and pleura.The tumor cells were epithelioid,spindled or polygonal-shaped and exhibited cord-like or small nest growth pattern.Some tumor cells formed cytoplasmic vacuoles, which contained erythrocytes.The tumor cells showed abundant eosinophilic cytoplasm.The stroma varied from highly myxoid to hyaline.In 3 cases, the tumors contained areas with significant atypia, brisk mitotic activity and necrosis.Immunohistochemical study showed that the tumor cells were positive for CD31, ERG, FLI-1, CD34, factor Ⅷ and CKpan to different extents.Follow-up information was available in 10 patients with duration ranging from 8 to 65 months.Seven patients were alive and three died.Conclusions EHE is easily a rare maligant vascular tumor,occurs in many organs other than soft tissue.EHE is misdiagnosed as carcinoma for its significant epithelioid morphology.Recognizing its clinicopathologic characteristics and combined application of specific vascular endothelial immunohistochemical markers are important to avoid confusion with other lesions.
