Research progress of ultra-long-acting local anesthetics
10.12089/jca.2024.08.019
- VernacularTitle:超长效局麻药的研究进展
- Author:
Wei LI
1
;
Yang ZHANG
;
Yuqi HUANG
;
Aiping WEI
;
Shibiao CHEN
Author Information
1. 330006 南昌大学第一附属医院麻醉科
- Keywords:
Ultra-long-acting local anesthetics;
Liposomal bupivacaine;
Meloxicam;
Quaternary lidocaine derivatives;
Nerve block
- From:
The Journal of Clinical Anesthesiology
2024;40(8):881-885
- CountryChina
- Language:Chinese
-
Abstract:
Multimodal analgesia is the gold standard for postoperative pain management,and ultra-sound-guided nerve block as the cornerstone supplemented with fewer opioids and a sufficient amount of non-steroidal anti-inflammatory drugs(NSAIDs)throughout the entire course of the procedure is the most main-stream multimodal analgesic regimen at present.However,ultrasound-guided nerve blocks are limited by the duration of action of local anesthetics and often provide effective analgesia for surgical patients for no more than 8 hours,resulting in a low satisfaction rate of postoperative analgesia in surgical patients.With the con-tinuous research on the concept of rapid rehabilitation,how to extend the duration of action of local anesthet-ics is the focus and hotspot of research.Ultra-long-acting local anesthetics include liposomal bupivacaine and HTX-011,which have been applied in clinical practice,and quaternary ammonium derivatives,which are still in the research stage.In this paper,we will review the existing ultra-long-acting local anesthetics in terms of ultra-long-acting local anesthetics with extended-release systems,new pathways and targets of ultra-long-acting local anesthetics,and the development of ultra-long-acting local anesthetics in the form of brand-new compounds,so as to provide new ideas for the subsequent research and clinical application of ultra-long-acting local anesthetics.
