Significance of P504s in distinction between solid pseudopapillary tumor of pancreas and pancreatic neuroendocrine tumors
10.3760/cma.j.issn.0529-5807.2015.05.006
- VernacularTitle:P504s 在胰腺实性假乳头瘤和胰腺神经内分泌肿瘤鉴别诊断中的价值
- Author:
Zhenwei CHEN
1
;
Hongqi SHI
;
Lixiong YING
;
Xiaoli ZHAI
;
Xiaodan FU
;
Qingwei LIU
;
Shanxian LOU
Author Information
1. 321000,浙江省金华市中心医院病理科
- Keywords:
Pancreatic neoplasms;
Neuroendocrine tumors;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2015;(5):320-322
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of P504s in differential diagnosis between solid pseudopapillary tumor of the pancreas(SPTP) and pancreatic neuroendocrine tumors(PanNET).Methods Forty-three patients with SPTP and 41 patients with PanNET encountered during the period from 2007 to 2014 were recruited.Immunohistochemical study for vimentin, CD10, chromogranin A, synaptophysin, beta-catenin, CD99 and P504s in SPTP and PanNET was performed.The diagnostic value of P504s in differentiating SPTP from PanNET was analyzed. Results Immunohistochemical study showed that vimentin, CD10, chromogranin A, synaptophysin and CD99 were expressed both in SPTP and PanNET.All cases of SPTP showed granular cytoplasmic expression of P504s, whereas those of PanNET were negative. Conclusion P504s is a sensitive and useful marker for SPTP and can be used in the distinction between SPTP and PanNET.
