Different methods to prevent first Rituximab transfusion anaphylaxis
10.3760/cma.j.issn.1674-2907.2015.30.035
- VernacularTitle:利妥昔单抗注射液首次输注不同方法防止过敏反应的研究
- Author:
Quanying? WU
1
;
Lei WANG
;
Man YANG
;
Peng YANG
Author Information
1. 100730 卫生部北京医院E04血液内分泌
- Keywords:
Transfusion,intravenous;
Anaphylxis;
Rituximab
- From:
Chinese Journal of Modern Nursing
2015;(30):3706-3707
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the best method for first Rituximab transfusion, in order to reduce the incidence of anaphylaxis. Methods A total of 157 non Hodgkin lymphoma patients with first Rituximab transfusion were divided into three groups according to random number table, within 55 cases in control group and the patients of control group undergoing Rituximab instruction advised transfusion method (50 ml/h). There were 62 patients in observation 1 group who received the beginning transfusion speed 10 ml/h and changed the speed every 30 min. There were 40 cases in observation 2 group who accepted the beginning speed 20 ml/h and changed speed every 30 min. The anaphylaxis in the three groups were observed and statistically analyzed. Results The anaphylaxis rates were 9. 7% in the observation 1 group and 25. 7% in the observation 2 group and 30. 9% in the control group. Compared three groups, the differences of anaphylaxis incidence were statistically significant between observation 1 group and the observation 2 group, control group (P<0. 05). The difference of anaphylxis incidences were not statistically significant between the observation 2 group and the control group (P>0. 05). Conclusions For first Rituximab transfusion, the beginning of 10 ml/h transfusion speed and changing speed every 30 min can effectively minimize anaphylxis incidence caused by Rituximab transfusion.
