Expression of Girdin in brain tissues of Alzheimer′s disease

VernacularTitle:Girdin 蛋白在阿尔茨海默病患者脑组织中的表达
Author: Longteng LIU ¹ ; Ping JIANG ; Di CUI ; Jun DU ; Lei HE ; Jingjing YAO ; Dongge LIU
Author Information

1. 100730,卫生部北京医院病理科
Keywords: Alzheimer disease; Microfilament proteins; Amyloid; Immunohistochemistry
From: Chinese Journal of Pathology 2015;(5):301-304
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of Girdin and its significance in Alzheimer′s disease ( AD).Methods Fifty-nine autopsy cases from Department of Pathology, Beijing Hospital from January 1988 to December 2013, including 35 AD cases and 24 non-AD cases as control.Girdin and amyloid β-protein ( Aβ) expression was evaluated immunohistochemically by EnVision method.The correlation between Girdin and Aβwas analyzed.Results Girdin expression was localized in the nucleus and/or cytoplasm.The expression rates of Girdin were 20.0% ( 7/35 ) in the AD group and 83.3%(20/24) in the non-AD group, respectively.The difference was significant ( Yates′s correction for continuityχ2 =20.527, P<0.05).Girdin expression and Aβdeposition also correlated significantly ( P<0.05).Conclusions Girdin shows reduced expression in AD, and is correlated positively with Aβdeposition.This suggests that Girdin may play an important role in the occurrence and development of AD.