Effect of esketamine on cognitive function in patients with major depressive disorder after electro-convulsive therapy
10.12089/jca.2024.07.010
- VernacularTitle:艾司氯胺酮对重度抑郁症患者电休克治疗后认知功能的影响
- Author:
Mengdi XUE
1
;
Zhiguo LI
;
Shaoxing WANG
;
Jiaxuan HUANG
;
Yanqing ZHANG
Author Information
1. 030001 太原市,山西医科大学麻醉学院
- Keywords:
Major depressive disorder;
Electroconvulsive therapy;
Esketamine;
Cognition
- From:
The Journal of Clinical Anesthesiology
2024;40(7):723-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of esketamine on depression and improvement of postoperative cognitive function in patients with major depressive disorder treated by electroconvulsive therapy(ECT).Methods A total of 115 patients with major depressive disorder,37 males and 78 fe-males,aged≥12 years,BMI 18-30 kg/m2,ASA physical status Ⅰ or Ⅱ were selected to receive ECT.The patients were randomly divided into two groups using a random number table:the esketamine group(group E,n=56)and the control group(group C,n=59).Group E received esketamine,propofol,and succincholine during anesthesia induction,and group C received propofol and succincholine during an-esthesia induction.ECT indicators(including EEG twitch time,twitch time,stimulus intensity,and twitch energy index)were recorded during each ECT session.Montreal cognitive assessment(MoCA)and Mini-mental state examination(MMSE)were used to evaluate cognitive function at baseline and after ECT treat-ment.Hamilton depression(HAMD)scale was used to score depression.The occurrence of headache,nau-sea,vomiting,dizziness,delirium,and other adverse reactions were recorded.Results Compared with group C,the EEG convulsion time in group E was significantly prolonged(P＜0.05),the incidence of Mo-CA score decreased by≥1 point and MMSE score decreased by≥1 point in group E after the end of ECT treatment was significantly reduced(P＜0.05),the incidence of nausea,vomiting,and dizziness were sig-nificantly decreased(P＜0.05).Conclusion Using esketamine in ECT for the treatment of major depres-sive disorder can improve cognitive function after ECT.
