Clinicopathologic features of clear cell papillary renal cell carcinoma
10.3760/cma.j.issn.0529-5807.2014.11.003
- VernacularTitle:透明细胞乳头状肾细胞癌的临床病理学分析
- Author:
Qiu RAO
1
;
Qin SHEN
;
Shanshan SHI
;
Qiuyuan XIA
;
Zhenfeng LU
;
Bo YU
;
Rusong ZHANG
;
Yan HE
;
Xuan WANG
;
Henghui MA
;
Xiaojun ZHOU
Author Information
1. 210002,南京军区南京总医院病理科 南京大学医学院附属金陵医院
- Keywords:
Carcinoma,renal cell;
Carcinoma,papillary;
Immunohistochemistry;
In situ hybridization,fluorescence
- From:
Chinese Journal of Pathology
2014;(11):728-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicopathological features , differential diagnosis and prognosis of clear cell papillary renal cell carcinoma ( CCPRCC ).Methods The histological , immunohistochemical , and molecular features were studied in 11 cases and follow-up data were also analyzed.Results There were a total of 3 females and 8 males.The age of patients were ranged from 33 to 72 years ( mean age 52.5 years).The diameters of tumors varied from 1cm to 4 cm.Histologically, papillary and cystic architecture were present at least focally in all tumors.The papillae were covered by small to medium-sized cuboidal cells with abundant clear cytoplasm and often showed extensive secondary branching , which were often folded and densely packed , resulting in a solid appearance.The nuclei were round and uniform in shape;nucleoli were not prominent ( Fuhrman grade 1 or 2 ).Neither mitotic figures nor necrosis was present.All 11 cases exhibited moderate to strong positivity for CK7, CA9, vimentin, and HIF-1α, coupled with negative reactions for CD10, P504S, and TFE3.Ksp-cadherin was positively expressed in 8 cases.VHL gene mutations were not found in all 11 cases.Losses of chromosomes 3 (monoploid chromosome 3) was detected in 3 cases.Conclusions CCPRCC is uncommon and seemed to be an indolent tumor.The differential diagnosis should be included tumors , which harbor clear cell and papillary structure including clear cell renal cell carcinoma , papillary renal cell carcinoma , Xp11 translocation renal cell carcinoma , and CCPRCC.Immunohistochemical and molecular analysis may be help for its diagnosis.
