Relationship between hypoxia inducible factor-1αand esophageal squamous cell carcinoma：a meta analysis
10.3760/cma.j.issn.0529-5807.2014.09.005
- VernacularTitle:低氧诱导因子-1α与食管鳞癌关系的M eta 分析
- Author:
Shaowu JING
1
;
Jun WANG
;
Qing LIU
;
Yunjie CHENG
;
Congrong YANG
;
Yi WANG
;
Feng CAO
;
Bin WEN
;
Wenpeng JIAO
;
Yin GUO
Author Information
1. 河北医科大学第四医院放疗科
- Keywords:
Esophageal neoplasms;
Anoxia;
Carcinoma,squamous cell;
Neoplasm invasiveness
- From:
Chinese Journal of Pathology
2014;(9):593-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of hypoxia inducible factor-1α( HIF-1α) in esophageal squamous cell carcinoma and its correlation with clinicopathological features .Methods Original literatures in foreign languages regarding correlation between HIF-1αand esophageal squamous cell carcinoma were identified from Cochrane Library , PubMed, EMbase database, and Chinese original literatures were from CBM , CNKI.All analyses were performed by Stata 11.0 software.Histological grade , degree of differentiation, T stage, lymph node metastasis, tumor stage, lymphatic invasion and vascular invasion were analyzed using pooled odds ratio (OR) with 95%confidence interval (CI).Results A total of 14 studies including 1 121 patients were enrolled in this meta analysis.Comparing with normal tissue , the expression of HIF-1αin esophageal squamous cell carcinoma was significantly enhanced ( OR=0.088, 95%CI:0.061-0.129, P=0.000);HIF-1αwas significantly associated with T stage and lymph node metastasis (OR=0.421, 95% CI:0.222-0.798, P=0.008; OR=0.387, 95% CI:0.207-0.725, P=0.003). High expression of HIF-1αwas correlated with an increased depth of tumor invasion , more lymph node metastasis and advanced tumor stage , whereas there was no relation to the degree of differentiation , histological grade, tumor stage, lymphatic invasion and vascular invasion.Conclusions High expression of HIF-1αprotein correlates with an increased risk of esophageal squamous cell carcinoma.HIF-1αmay be an indicator for T stage , lymph node metastasis and tumor stage , but further studies are needed.
