Clinicopathological significance of gastric mucosal infection with coccoid Helicobacter pylori

VernacularTitle:胃黏膜中单纯球形幽门螺杆菌感染的临床病理意义
Author: Dongbing ZHU ¹ ; Li SHA ; Xiaojian SHEN ; Jing HUAN ; Haiyun WANG
Author Information

1. 226500江苏省如皋市人民医院病理科
Keywords: Gastric mucosa; Gastritis; Helicobacter pylori; Immunohistochemistry
From: Chinese Journal of Pathology 2014;(5):326-329
CountryChina
Language:Chinese
Abstract: Objective To study the detection method of coccoid helicobacter pylori ( HP) and to investigate the significance of pure coccoid HP infection of gastric mucous membrane.Methods A total of 171 gastric biopsy specimens were reviewed by HE stain ,and the presence , density and tissue distribution of HP were investigated by sliver stain and immunohistochemistry ( S-P method ).Results The rates of mucosal erosion and active inflammation with the presence of pure coccoid HP infection were 36.0%(9/25) and 44.0%(11/25), respectively, both higher than those without HP infection (13.5%,10/74;24.3%, 18/74), while lower than those infected with spiral HP (72.1%,49/68;79.4%,54/68).The quantity of interstitial lymphocyte and inflammation severity were also higher than those without HP infection , while lower than those with spiral HP infection.Conclusions Pure coccoid HP causes human gastritis , similar to that of spiral HP infection but at a lesser degree.Further studies are important to confirm its clinical significance.