Pharmacodynamic interaction of esketamine and propofol in hysteroscopic surgery
10.12089/jca.2024.06.010
- VernacularTitle:艾司氯胺酮和丙泊酚在宫腔镜手术中的药效学相互作用
- Author:
Yan LI
1
;
Jiaqi TAN
;
Ziyu LI
;
Jintai JIA
;
Ping ZHUANG
Author Information
1. 030000 太原市,山西医科大学麻醉学院
- Keywords:
Esketamine;
Propofol;
Response surface methodology;
Pharmacodynamic interaction;
Target-controlled infusion
- From:
The Journal of Clinical Anesthesiology
2024;40(6):612-616
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the pharmacodynamic interaction of esketamine and propofol in hysteroscopic surgery by response surface method.Methods Forty-five patients underwent elective hystero-scopic surgery,aged 18.5-64.0 years,BMI 18.5-28.0 kg/m2,ASA physical status Ⅰ or Ⅱ.Compound propofol target control infusion of esketamine(0,0.1,0.2,0.3,0.4,0.5,0.6,0.7,and 0.8 μg/ml)with different plasma drug concentrations were selected to keep the plasma drug concentration of esketamine unchanged,and the plasma drug concentration of propofol was increased step by step.To evaluate body re-sponse caused by dilation of the cervix.A response surface model was used to analyze the pharmacodynamic interaction of esketamine and propofol.Results The three-dimensional response surface of esketamine(0.0-0.8 μg/ml)and propofol(1.0-7.0 μg/ml)showed that the two have an additive effect in sedation and inhibition of body activity reaction caused by dilated cervix.The median effective concentration(EC50)of esketamine was 0.61 μg/ml(95％CI 0.41-0.81 μg/ml),and the EC50 of propofol was 4.69 μg/ml(95％CI 3.17-6.21 μg/ml)when inhibits the body activity reaction caused by dilated cervix.Conclusion Response surface method can qualitatively and quantitatively analyze the pharmacodynamic interaction of es-ketamine and propofol.Esketamine and propofol have additive effects in inhibiting the body activity reaction caused by dilated cervix.
