Clinical Features and Prognostic Factors of Anaerobic Infections: A 7-Year Retrospective Study.
10.3904/kjim.2009.24.1.13
- Author:
Yoonseon PARK
1
;
Jun Young CHOI
;
Dongeun YONG
;
Kyungwon LEE
;
June Myung KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. jmkim@yuhs.ac
- Publication Type:Original Article ; Comparative Study
- Keywords:
Anaerobic bacteria;
Prognosis
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Anti-Bacterial Agents/*therapeutic use;
Bacteria, Anaerobic/*isolation & purification;
Bacterial Infections/*epidemiology/microbiology/therapy;
Drainage/methods;
Female;
Follow-Up Studies;
Humans;
Korea/epidemiology;
Male;
Middle Aged;
Morbidity/trends;
Prognosis;
Retrospective Studies;
Survival Rate/trends;
Time Factors;
Young Adult
- From:The Korean Journal of Internal Medicine
2009;24(1):13-18
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Risk factors for mortality resulting from anaerobic infection are incompletely defined. The clinical significance of a broad range of pathogenic obligate anaerobic organisms was examined, and factors independently associated with mortality were identified in patients with clinically significant anaerobic infections. METHODS: The medical records of 1,050 patients with anaerobic infections were retrospectively reviewed at Severance Hospital in Seoul, Korea. RESULTS: The mean age of the patients was 54.1+/-16.8 years, and 57.7% were men. Overall, 320 (30.5%) patients with case-defined illness experienced pain at the affected site, and 230 (21.9%) experienced pus flow from lesions. Ten (1.4%) patients presented with shock, and 80.3% of the clinically significant cases were polymicrobial anaerobic infections. The mean number of pathogens, including aerobic and anaerobic bacteria, was 3.7+/-1.0 (minimum 1, maximum 5), and the number of anaerobic organisms was 1.0+/-0.3 in each specimen. The major pathogens by rank were the Bacteroides fragilis group, which accounted for 41.8% of anaerobic infections, followed by Clostridium spp. (11.8%), Prevotella spp. (9.4%), and Peptostreptococcus spp. (8.4%). Escherichia coli (17.5%), Staphylococcus aureus (7.5%), and Klebsiella pneumoniae (7.5%) were common concomitant aerobic organisms. The overall crude mortality rate resulting from anaerobic infection was 29.7%. Among the determining factors associated with mortality, liver disease (p=0.003) and old age (p=0.005) were significant in multivariate analysis. CONCLUSIONS: Anaerobic infection is polymicrobial and has a significant role in morbidity and mortality. Underlying liver disease was associated with poor prognosis in anaerobic infection.
