Expression of cytokeratin 7 and 20 in ovarian metastatic carcinomas
10.3760/j.issn:0529-5807.2001.02.008
- VernacularTitle:细胞角蛋白7和20在卵巢转移癌中的表达
- Author:
Lin DAI
1
;
Qiujing SONG
;
Lihua LI
;
Dajun ZHONG
;
Yunzhong HUI
Author Information
1. 北京大学医学部第二临床医学院(北京人民医院)
- From:
Chinese Journal of Pathology
2001;30(2):114-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distinctive clinicopathologic and immunohis tochemical difference between ovarian metastatic carcinomas and primary ovarian carcinom as. Methods The clinical and pathological features of 27 cases of ovaria n metastatic carcinomas (gastric carcinomas 12 cases, colon carcinomas 11 cases, others 4 cases) obtained from our department were reviewed. Immunostaini ngs for CK(AE1/AE3), CK7, CK20,CEA, vimentin, nm23 were performed with SP staini ng methods. Results On gross examination, metastasis from gastric adenocarcinoma were usually bilateral, while solid (11/12) and metastases from colonic adenoca rcinoma were more often unilateral and cystic (7/11). Microscopically, metastases fr om gastric adenocarcinoma revealed signet ring cells or poorly differentiated adenocarcinom as (12/12), whereas metastases from colonic adenocarcinomas showed similar morph ology of endometrioid adenocarcinoma (8/11). The majority of ovarian metastases of gastr ic car cinoma (7/12) and colon carcinoma (8/11) were CK20 positive. In particular, CK20 was invariably expressed in colon cancer metastases. Most of the ovarian metastatic carcinomas from the gastrointestinal tract failed to react with immunostaining of CK7. A combined use of CEA, vimentin and nm23 had made a correct classification for 11/ 12 cases of the gastric carcinoma, 10/11 cases of the colonic cancer. Conclusions CK7 and CK20 have been proved to be useful antibodies in distinguishing b etween metastatic carcinomas and primary carcinomas of the ovary. Combined use of a panel of antibodies can give more significant results.
