Cytotoxic natural killer/T-cell lymphomas of the lymph nodes
10.3760/j.issn:0529-5807.2001.02.005
- VernacularTitle:淋巴结细胞毒性自然杀伤/T细胞淋巴瘤
- Author:
Tao LIN
1
;
Weiping LIU
;
Gandi LI
;
Fengyuan LI
;
Ju YUAN
Author Information
1. First University Hospital West-China University of Medical Sciences
- From:
Chinese Journal of Pathology
2001;30(2):101-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathologic features of cytotoxi c natural killer (NK)/T-cell lymphomas of the lymph nodes. Methods Clinicopatho logic observations and follow up on 5 cases of cytotoxic NK/T-cell lymphomas of the lymph nodes, immunohistochemical staining for CD45RO,CD8,CD56,CD30,CD20,TIA -1 and in situ hybridization for EBER1/2 were performed. Results (1) The clinico pathologic features of cytotoxic NK-T-cell lymphomas of the lymph nodes were s um marized; (2) The tumor cells were positive for CD45RO in 4 of the 5 cases, in wh ich 3 cases were also positive for CD56. One case was of null cell type. The tum or cells were positive for TIA-1 and EBER1/2 in all 5 cases. Conclusions The clin icopathological features and special immunophenotypes of cytotoxic NK/T-cell ly m phomas of the lymph nodes were present in all 5 cases. Clinically, this entity t ends to be an aggressive process with poor prognosis.
