Primary cutaneous CD30-pos itive anaplastic large cell lymphoma
- VernacularTitle:皮肤原发性CD30阳性间变性大细胞淋巴瘤
- Author:
Qunli SHI
1
;
Xinyu XU
;
Honglin YIN
;
Xiaojun ZHOU
;
Tong ZHANG
;
Guiqin SUN
;
Shamoto MIKIHIRO
;
Bin QIAN
Author Information
1. Nanjing General Hospital of PLA
- From:
Chinese Journal of Pathology
2001;30(2):97-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the clinical manifestations, pathoogical and immunohistochemica l features of 9 cases of primary cutaneous CD30-positive anaplastic large cell ly mphoma (ALCL) in order to improve the criteria for its early and differential diagnosis. Methods Histopathological method was used to study the morphological characteristics. Immunohistochemical stainings (SP or ABC method) for leukocyte common antigen (LCA), CD20, CD30, CD45RO, CD68, epithelium membran e antigen (EMA), cytokeratin (CK) and HMB45 were applied to the routine para ffin sections of all the 9 cases. Results The 9 cases of primary cutaneous CD30-pos itive ALCL consisting of 6 males and 3 females, aged 31 to 84 years (mean 58.2 years). All patients presented with subcutaneous masses or papular eruptions on lower trunk and extremities. Histopatholoically, the lesions were composed of nu merous large round, oval or pleomorphic cells with abundant cytoplasm, amphophil ic or basophilic, and large nucleus with distinct nucleolus. Mitosis was often o bserved. Multinucleated giant cells and Reed-Sternberg cells may be seen. The n e oplastic cells displayed positive antigen markers for CD30 in 9 cases, 6 positiv e for CD45RO and 3 cases negative for both CD45RO and CD20. Two patients died of metastasis, 2 patients experienced recurrence and 5 patients still well during follow-up. Conclusions Primary cutaneous CD30-positive ALCL is a morphologically distinctive neoplasm with a comparatively favorable prognosis. This tumor can be differentiated from other malignant tumors on the basis of histopathologic feat ures and positive CD30 which is of significance.
